Introduction: The aim of this study was to investigate the multiple relationships between emotional regulation strategies, pain self-efficacy and disease perception with psychological wellbeing in women with breast cancer in Isfahan city. Method: A descriptive correlational research design were administered and statistical population included all breast cancer women referred to Isfahan health centers in the Spring 2018. Consequently, 160 breast cancer women were selected by available sampling method and based on inclusion/exclusion criteria. Data collection tools consisted of Gross and John's Emotion Regulation Questionnaires, Nicholas pain Self-Efficacy Inventory (PSEQ), Bradbent et. al Illness Perception Questionnaire (IPQ) and Reif's Psychological Well-being Questionnaire(RPWS). Results: The results showed that there is a positive and significant correlation between re-evaluation strategy(0/20), understanding the outcomes(0/16), personal control(0/17), treatment control(0/16) and total score of Perception of Disease(0/17) with psychological well-being in women with cancer. The results of a regression analysis showed that among all variables 1-perceived illness outcome and 2-reappraisal strategy could significantly predict changes in the psychological well-being of breast cancer women. Two variables could explain 8% of the variance of psychological well-being. Conclusion: According to the results, changes in the re-evaluation strategy and understanding the outcomes of the disease are associated with changes in the psychological well-being of women with breast cancer. Therefore, by recognizing and understanding deeper psychological characteristics and beliefs about the disease in women with breast cancer, they can take steps to increase their psychological well-being with new conditions.